The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2017
Filed:
Sep. 11, 2012
Applicants:
Bruce Scharschmidt, San Francisco, CA (US);
Masoud Mokhtarani, Walnut Creek, CA (US);
Inventors:
Bruce Scharschmidt, San Francisco, CA (US);
Masoud Mokhtarani, Walnut Creek, CA (US);
Assignee:
Horizon Therapeutics, LLC, Lake Forest, IL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/192 (2006.01); A61K 31/216 (2006.01); A61K 31/225 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 31/192 (2013.01); A61K 31/216 (2013.01); G01N 33/6812 (2013.01);
Abstract
The present disclosure provides methods for adjusting the dosage of PAA prodrugs (e.g., HPN-100, PBA) based on measurement of PAA and PAGN in plasma and calculating the PAA:PAGN ratio so as to determine whether PAA to PAGN conversion is saturated.