The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2017
Filed:
Jun. 16, 2015
Applicant:
Biomarin Pharmaceutical Inc., Novato, CA (US);
Inventors:
Erik Damien Foehr, San Rafael, CA (US);
Bin Zhao, San Ramon, CA (US);
Carlos Fabricio Santamaria, San Francisco, CA (US);
Assignee:
BIOMARIN PHARMACEUTICAL INC., Novato, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G01N 33/573 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6854 (2013.01); G01N 33/573 (2013.01); G01N 2333/988 (2013.01);
Abstract
Provided herein are methods of detecting the presence of a pegylated enzyme, an enzyme-specific antibody (e.g., a neutralizing antibody or of a particular isotype), or a polyethylene glycol (PEG)-specific antibody in a sample, such as a bodily fluid or tissue of a patient. In certain embodiments, the enzyme is phenylalanine ammonia-lyase (PAL), such as(Av) PAL administered to the patient as part of an enzyme substitution therapy for diseases or disorders, such as phenylketonuria (PKU), or cancer therapy.