The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2017
Filed:
Feb. 26, 2008
Applicant:
Dave S. B. Hoon, Los Angeles, CA (US);
Inventor:
Dave S. B. Hoon, Los Angeles, CA (US);
Assignee:
JOHN WAYNE CANCER INSTITUTE, Santa Monica, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 6/00 (2006.01); A61K 9/00 (2006.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 31/00 (2006.01); A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 31/713 (2006.01); A61K 47/00 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/156 (2013.01);
Abstract
The present invention discloses a method of detecting a wild-type or mutant B-RAF gene in a body fluid sample from a subject. Also disclosed are methods of using B-RAF as a biomarker for detecting cancer, predicting the outcome of cancer, and monitoring the treatment of cancer or the status of cancer. Furthermore, the invention discloses methods and compositions for detecting a mutant gene with a peptide nucleic acid clamp capable of hybridizing to a wild-type gene and a locked nucleic acid probe capable of hybridizing to a mutant of the gene.