The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2017
Filed:
Dec. 20, 2007
Rahmi Lale, Trondheim, NO;
Laila Berg, Trondheim, NO;
Ingrid Bakke, Ranheim, NO;
Trond Erik Vee Aune, Trondheim, NO;
Svein Valla, Vikhammer, NO;
Rahmi Lale, Trondheim, NO;
Laila Berg, Trondheim, NO;
Ingrid Bakke, Ranheim, NO;
Trond Erik Vee Aune, Trondheim, NO;
Svein Valla, Vikhammer, NO;
VECTRON BIOSOLUTIONS AS, Trondheim, NO;
Abstract
The present invention concerns a method of producing a desired gene product in a recombinant gene expression system, said method comprising expressing said gene from a Pm promoter-based expression system using at least two mutant elements selected from: (i) a mutant Pm promoter; (ii) a mutant mRNA leader; and (iii) a mutant XyIS; wherein said mutant elements each comprise one or more mutations which enhance expression of said desired gene. Particularly combinations of a mutant Pm promoter and a mutant mRNA leader are concerned. Isolated nucleic acid molecules, vectors, host cells, libraries, expression systems, methods of enhancing expression, obtaining nucleic acid molecules and identifying combination mutants which enhance expression, artificially constructed operons and their uses are also encompassed.