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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9556426 B1

PDFFull Text
Date of Patent:
Jan. 31, 2017

Filed:

Sep. 15, 2010

Protein kinase conjugates and inhibitors

Applicants:

Juswinder Singh, Ashland, MA (US);

Russell Colyn Petter, Stow, MA (US);

Deqiang Niu, Lexington, MA (US);

Lixin Qiao, Andover, MA (US);

Arthur Kluge, Lincoln, MA (US);

Roy Lobb, Westwood, MA (US);

Shomir Ghosh, Brookline, MA (US);

Zhendong Zhu, Westborough, MA (US);

Inventors:

Juswinder Singh, Ashland, MA (US);

Russell Colyn Petter, Stow, MA (US);

Deqiang Niu, Lexington, MA (US);

Lixin Qiao, Andover, MA (US);

Arthur Kluge, Lincoln, MA (US);

Roy Lobb, Westwood, MA (US);

Shomir Ghosh, Brookline, MA (US);

Zhendong Zhu, Westborough, MA (US);

Assignee:

Celgene Avilomics Research, Inc., Cambridge, MA (US);

Attorney:

Jones Day

Primary Examiner:

Amber D Steele

Int. Cl.
CPC ...
C12N 9/96 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); A61K 47/48 (2006.01); C07D 213/74 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 215/22 (2006.01); C07D 231/12 (2006.01); C07D 239/42 (2006.01); C07D 239/48 (2006.01); C07D 333/68 (2006.01); C07D 401/12 (2006.01); C07D 403/14 (2006.01); C07D 409/04 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C12N 9/96 (2013.01); A61K 47/48061 (2013.01); A61K 47/48238 (2013.01); C07D 213/74 (2013.01); C07D 213/81 (2013.01); C07D 213/82 (2013.01); C07D 215/22 (2013.01); C07D 231/12 (2013.01); C07D 239/42 (2013.01); C07D 239/48 (2013.01); C07D 333/68 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 409/04 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01); C12N 9/1205 (2013.01);
Abstract

The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.

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