The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2017
Filed:
Dec. 28, 2012
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Hirotake Shiraiwa, Shizuoka, JP;
Keiko Esaki, Shizuoka, JP;
Tomoyuki Igawa, Shizuoka, JP;
Taichi Kuramochi, Shizuoka, JP;
Atsuhiko Maeda, Shizuoka, JP;
Shigero Tamba, Shizuoka, JP;
Hiroyuki Tsunoda, Shizuoka, JP;
Tatsuhiko Tachibana, Shizuoka, JP;
Yasuko Kinoshita, Kanagawa, JP;
Masami Suzuki, Shizuoka, JP;
Atsuhiko Kato, Shizuoka, JP;
Etsuko Takeiri, Shizuoka, JP;
Eri Hashimoto, Kanagawa, JP;
Yoshinori Watanabe, Kanagawa, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
The inventors successfully produced anti-Epiregulin antibodies showing cross-species reactivity between cynomolgus monkey (non-human animals) and human, anti-Epiregulin antibodies with suppressed chemical degradation, anti-Epiregulin antibodies with lowered isoelectric point, anti-Epiregulin antibodies with increased thermal denaturation midpoint temperature, and anti-Epiregulin antibodies with reduced amount of aggregate by performing appropriate amino acid residue substitutions in the variable-region sequences of the humanized EP27 antibody which inhibits growth of cancer cells by exhibiting cytotoxic activity and neutralizing activity against human Epiregulin-expressing cancer cells.