The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 31, 2017

Filed:

Jul. 16, 2013
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Albert J. DelMonte, Belle Mead, NJ (US);

Kenneth J. Natalie, Jr., Flemington, NJ (US);

Kenneth J. Fraunhoffer, Princeton, NJ (US);

Christina Ann Risatti, Clarksburg, NJ (US);

Chao Hang, Monmouth Junction, NJ (US);

Zhinong Gao, Princeton, NJ (US);

Akin H. Davulcu, Yardley, PA (US);

Wenhao Hu, Shanghai, CN;

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 62/10 (2006.01); C07C 69/734 (2006.01); C07C 69/757 (2006.01); C07D 209/08 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); C07C 211/45 (2006.01); C07C 233/05 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); C07C 62/10 (2013.01); C07C 69/734 (2013.01); C07C 69/757 (2013.01); C07C 211/45 (2013.01); C07C 233/05 (2013.01); C07D 209/08 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention provides methods and intermediates for the preparation of (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.


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