The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2017
Filed:
Apr. 08, 2014
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Hongmei Zhao, Southborough, MA (US);
Nelson S. Yew, West Upton, MA (US);
Seng H. Cheng, Natick, MA (US);
Canwen Jiang, Southborough, MA (US);
Cynthia Marie Arbeeny, Marlborough, MA (US);
Assignee:
Genzyme Corporation, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/40 (2006.01); C07D 405/06 (2006.01); A61K 31/395 (2006.01); A61K 31/4245 (2006.01); A61K 31/4025 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 405/06 (2013.01); A61K 31/395 (2013.01); A61K 31/40 (2013.01); A61K 31/4025 (2013.01); A61K 31/4245 (2013.01); A61K 45/06 (2013.01);
Abstract
The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs.