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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9556148 B1

PDFFull Text
Date of Patent:
Jan. 31, 2017

Filed:

Aug. 06, 2014

N-cyanomethylamides as inhibitors of janus kinase

Applicant:

Cadila Healthcare Limited, Ahmedabad, Gujarat, IN;

Inventors:

Ranjit Desai, Gujarat, IN;

Jigar Desai, Gujarat, IN;

Pankaj Patel, Gujarat, IN;

Assignee:

Cadila Healthcare Limited, Ahmedabad, IN;

Attorney:

Ladas & Parry LLP

Primary Examiner:

Kahsay Habte

Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 417/14 (2006.01); C07D 413/14 (2006.01); C07D 403/14 (2006.01); C07D 409/10 (2006.01); C07D 409/14 (2006.01); C07D 498/08 (2006.01); C07D 513/08 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); C07D 407/12 (2006.01); C07D 407/14 (2006.01); C07D 409/12 (2006.01); C07D 471/08 (2006.01); C07D 491/056 (2006.01); C07D 491/08 (2006.01); C07D 491/107 (2006.01); C07D 495/08 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 407/12 (2013.01); C07D 407/14 (2013.01); C07D 409/10 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01); C07D 491/056 (2013.01); C07D 491/08 (2013.01); C07D 491/107 (2013.01); C07D 495/08 (2013.01); C07D 498/08 (2013.01); C07D 513/08 (2013.01);
Abstract

The present invention relates to compounds of general formula (1) that are inhibitors of Janus Kinase (JAK), a family of tyrosine kinases that are involved in inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. In particular, the compound of the invention inhibits JAK1 and/or JAK2 and/or JAK3 sub families. The present invention also provides methods for the production of the compounds of the invention, pharmaceutical compositions comprising the compounds of the invention, their tautomeric forms, and their pharmaceutically acceptable salts

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