The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 31, 2017

Filed:

Oct. 09, 2009
Applicants:

Edward Peter Rybicki, Pinelands, ZA;

Ann Elizabeth Meyers, Plumstead, ZA;

François Devesa, Launaguet, FR;

Pablo Marzábal Luna, Barcelona, ES;

Inga Isabel Hitzeroth, Cape Town, ZA;

Peter Öhlschläger, Constance, DE;

Inventors:

Edward Peter Rybicki, Pinelands, ZA;

Ann Elizabeth Meyers, Plumstead, ZA;

François Devesa, Launaguet, FR;

Pablo Marzábal Luna, Barcelona, ES;

Inga Isabel Hitzeroth, Cape Town, ZA;

Peter Öhlschläger, Constance, DE;

Assignee:

ERA BIOTECH, S.A., Cerdanyola del Vallès, Barcelona, ES;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); C07K 14/005 (2006.01); C07K 14/415 (2006.01); C07K 14/425 (2006.01); C12N 7/00 (2006.01); C12N 15/62 (2006.01); C12N 15/82 (2006.01); A61K 39/12 (2006.01); A61K 39/385 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/21 (2013.01); A61K 39/0011 (2013.01); A61K 39/12 (2013.01); A61K 39/385 (2013.01); C07K 14/005 (2013.01); C07K 14/415 (2013.01); C07K 14/425 (2013.01); C12N 7/00 (2013.01); C12N 15/625 (2013.01); C12N 15/8216 (2013.01); C12N 15/8218 (2013.01); C12N 15/8257 (2013.01); C12N 15/8258 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/53 (2013.01); A61K 2039/54 (2013.01); A61K 2039/55516 (2013.01); A61K 2039/572 (2013.01); A61K 2039/575 (2013.01); A61K 2039/585 (2013.01); A61K 2039/6031 (2013.01); C07K 2319/04 (2013.01); C12N 2710/20022 (2013.01); C12N 2710/20034 (2013.01); C12N 2710/20071 (2013.01); C12N 2740/16022 (2013.01); C12N 2740/16034 (2013.01); C12N 2740/16122 (2013.01); C12N 2740/16222 (2013.01); C12N 2740/16234 (2013.01); C12N 2740/16322 (2013.01);
Abstract

An immunogen-specific is adjuvant for a vaccine or inoculum is disclosed. The adjuvant is comprised of particulate recombinant protein body-like assemblies (RPBLAs) that contain a recombinant fusion protein that contains two portions peptide-linked together. A first portion is a protein body-inducing sequence (PBIS) and a second portion is a T-cell stimulating immunogenic polypeptide whose sequence is that of a pathogenic polypeptide sequence present in or induced by a vaccine or inoculum. The adjuvant, when used as an inoculum in a host animal without a prior priming vaccination or inoculation, does not induce production of antibodies or T cell activation to the pathogenic sequence.


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