The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 31, 2017

Filed:

Jun. 13, 2008
Applicants:

Robert A. Rissman, San Diego, CA (US);

Kuo-fen Lee, Del Mar, CA (US);

Wylie W. Vale, La Jolla, CA (US);

Paul E. Sawchenko, Carlsbad, CA (US);

Inventors:

Robert A. Rissman, San Diego, CA (US);

Kuo-Fen Lee, Del Mar, CA (US);

Wylie W. Vale, La Jolla, CA (US);

Paul E. Sawchenko, Carlsbad, CA (US);

Assignee:

Research Development Foundation, Carson City, NV (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 38/22 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 38/2228 (2013.01); A61K 45/06 (2013.01); G01N 33/6896 (2013.01); G01N 2500/00 (2013.01); G01N 2800/2814 (2013.01); G01N 2800/2821 (2013.01);
Abstract

Methods for treating or preventing tauopathies and/or Aβ amyloidosis by modulating CRF receptor signaling. Accumulation of hyperphosphorlyated tau protein in the CNS may be reduced by administration of CRF-R1 selective antagonists and/or CRF-R2 selective agonists. For example, in some aspects, methods for preventing the onset of Alzheimer's disease by administration of CRF-R1 selective antagonist are provided.


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