The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2017
Filed:
Apr. 17, 2015
The Noguchi Institute, Tokyo, JP;
Immuno-biological Laboratories Co., Ltd., Fujioka-shi, Gunma, JP;
Takashi Shirai, Tokyo, JP;
Masako Mori, Tokyo, JP;
Masaki Kurogochi, Tokyo, JP;
Masahiro Tomita, Fujioka, JP;
THE NOGUCHI INSTITUTE, Tokyo, JP;
IMMUNO-BIOLOGICAL LABORATORIES CO., LTD., Fujioka-shi, JP;
Abstract
The present invention is aimed to provide a method for preparing an acceptor that is N-glycan hydrolyzed antibody or a Fc fragment thereof used for producing antibody having a homogeneous N-glycan structure; a method for determining a combination of endoglycosidases for use in said preparation; and a method for measuring N-glycans linked to an antibody. The present invention is directed to a method for producing a N-glycan hydrolyzed antibody or Fc fragment thereof, comprising reacting the antibody or the Fc fragment thereof with several endoglycosidases; and a method for determining quantitative information of an objective N-glycan with a desired structure linked to an antibody or a Fc thereof, comprising a protease treatment step and a glycopeptide measurement step, etc.