The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2017
Filed:
Aug. 05, 2015
Amgen Inc., Thousand Oaks, CA (US);
Jennifer R. Allen, Newbury Park, CA (US);
Albert Amegadzie, Moorpark, CA (US);
Matthew P. Bourbeau, Woodland Hills, CA (US);
James A. Brown, Moorpark, CA (US);
Jian J. Chen, Camarillo, CA (US);
Yuan Cheng, Newbury Park, CA (US);
Michael J. Frohn, Thousand Oaks, CA (US);
Angel Guzman-Perez, Belmont, MA (US);
Paul E. Harrington, Camarillo, CA (US);
Longbin Liu, Thousand Oaks, CA (US);
Qingyian Liu, Camarillo, CA (US);
Jonathan D. Low, Reseda, CA (US);
Vu Van Ma, Oak Park, CA (US);
James Manning, Pleasant Hill, CA (US);
Ana Elena Minatti, Santa Monica, CA (US);
Thomas T. Nguyen, Newbury Park, CA (US);
Nobuko Nishimura, West Hills, CA (US);
Mark H. Norman, Thousand Oaks, CA (US);
Liping H. Pettus, Thousand Oaks, CA (US);
Alexander J. Pickrell, Westlake Village, CA (US);
Wenyuan Qian, Thousand Oaks, CA (US);
Shannon Rumfelt, Camarillo, CA (US);
Robert M. Rzasa, Thousand Oaks, CA (US);
Aaron C. Siegmund, Ventura, CA (US);
Markian M. Stec, Thousand Oaks, CA (US);
Ryan D. White, Somerville, MA (US);
Qiufen Xue, Thousand Oaks, CA (US);
Amgen, Inc., Thousand Oaks, CA (US);
Abstract
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, A, A, A, and each of R, R, R, R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.