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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9550757 B1

PDFFull Text
Date of Patent:
Jan. 24, 2017

Filed:

Jun. 28, 2013

Nuclear transport modulators and uses thereof

Applicant:

Karyopharm Therapeutics Inc., Newton, MA (US);

Inventors:

Sharon Shacham, Newton, MA (US);

Michael Kauffman, Newton, MA (US);

Vincent P. Sandanayaka, Northboro, MA (US);

Sharon Shechter, Andover, MA (US);

Assignee:

Karyopharm Therapeutics Inc., Newton, MA (US);

Attorney:

Foley Hoag LLP

Primary Examiner:

Alicia L Otton

Int. Cl.
CPC ...
A61K 31/4196 (2006.01); A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/496 (2006.01); A61K 31/505 (2006.01); C07D 409/04 (2006.01); C07D 207/337 (2006.01); C07D 231/12 (2006.01); C07D 233/64 (2006.01); C07D 249/08 (2006.01); C07D 257/04 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 409/04 (2013.01); A61K 31/4196 (2013.01); A61K 31/433 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/505 (2013.01); C07D 207/337 (2013.01); C07D 231/12 (2013.01); C07D 233/64 (2013.01); C07D 249/08 (2013.01); C07D 257/04 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01);
Abstract

The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

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