The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2017
Filed:
May. 08, 2014
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
Jianqi Li, Shanghai, CN;
Xiaowen Chen, Shanghai, CN;
Zhilong Ma, Shanghai, CN;
Li Zhang, Shanghai, CN;
Ning Cui, Shanghai, CN;
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
Abstract
Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine Dreceptor, 5-HTreceptor and 5-HTreceptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof.