The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2017
Filed:
Apr. 05, 2012
Tashfeen Walton, Edinburgh, GB;
Mark Bradley, Edinburgh, GB;
Kev Dhaliwal, Edinburgh, GB;
Nikolaos Avlonitis, Edinburgh, GB;
Chris Haslett, Edinburgh, GB;
Neil Mcdonald, Edinburgh, GB;
Manuelle Debunne, Edinburgh, GB;
Tashfeen Walton, Edinburgh, GB;
Mark Bradley, Edinburgh, GB;
Kev Dhaliwal, Edinburgh, GB;
Nikolaos Avlonitis, Edinburgh, GB;
Chris Haslett, Edinburgh, GB;
Neil McDonald, Edinburgh, GB;
Manuelle Debunne, Edinburgh, GB;
THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH, Edinburgh, GB;
Abstract
The present invention relates to methods of visualizing cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalized by the cells and thus permits subsequent visualization by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualizing cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualizing cells by virtue of internalization and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.