The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2017
Filed:
Apr. 14, 2009
John R. Cashman, San Diego, CA (US);
Mary T. Macdonald, San Diego, CA (US);
John R. Cashman, San Diego, CA (US);
Mary T. MacDonald, San Diego, CA (US);
Human BioMolecular Research Institute, San Diego, CA (US);
Abstract
The present disclosure provides organophosphorous (OP) compounds of Formula (I), Formula (II) and Formula (III):OP-Peptide-Linker-CP  (I),OP-Peptide-Linker  (II); and including that structure corresponding to a reactive organophosphorous reagent, nerve agent or pesticide, or a pesticide P═S to P═O metabolite; P is the Sor Rstereoisomer; X is oxygen, sulfur, selenium or imino; R and R' are as described; Peptide is a sequence of amino acids containing a serine, threonine or tyrosine to which the OP is attached, wherein the total number of amino acids is between 7 and 41; Linker is an amino acid or is derived from another bifunctional reagent capable of covalently attaching an OP-peptide to a CP; and CP is a carrier protein used to display haptens for antibody generation. The disclosure also provides methods for generating monoclonal or polyclonal antibodies specific for an OP-Peptide of a compound of Formula (I) or Formula (II) that can be used to diagnose the presence, identity, and quantity of OP adducts.