The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2017
Filed:
Dec. 07, 2010
Arne Skerra, Freising, DE;
Michaela Gebauer, Leipzig, DE;
Dominik Hinz, Freising, DE;
Sabine Rauth, Traunreut, DE;
Gabriele Matschiner, Munich, DE;
Martin Huelsmeyer, Wolfersdorf, DE;
Arne Skerra, Freising, DE;
Michaela Gebauer, Leipzig, DE;
Dominik Hinz, Freising, DE;
Sabine Rauth, Traunreut, DE;
Gabriele Matschiner, Munich, DE;
Martin Huelsmeyer, Wolfersdorf, DE;
Pieris Pharmaceuticals GmbH, Freising, DE;
Abstract
The present invention relates to a novel library for the generation of muteins and to novel muteins derived from human lipocalin 2 (Lcn2, hNGAL) and related proteins that bind a given target with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. For example, such muteins may serve to bind and deplete pathological forms of natural biomolecules such as the amyloid beta peptide in Alzheimer's disease or may target the fibronectin extra-domain B, which is associated with tumor neovasculature.