The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2017
Filed:
Jul. 13, 2012
Anders H. Berg, Dedham, MA (US);
S. Ananth Karumanchi, Chestnut Hill, MA (US);
Ravi I. Thadhani, Boston, MA (US);
Anders H. Berg, Dedham, MA (US);
S. Ananth Karumanchi, Chestnut Hill, MA (US);
Ravi I. Thadhani, Boston, MA (US);
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.