The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 24, 2017

Filed:

Mar. 11, 2014
Applicant:

Arizona Board of Regents for and on Behalf ,of Arizona State University, Tempe, AZ (US);

Inventors:

Bruce Edward Rittmann, Tempe, AZ (US);

Rosa Krajmalnik-Brown, Chandler, AZ (US);

Husen Zhang, Tempe, AZ (US);

John Dibaise, Scottsdale, AZ (US);

Michael Crowell, Fountain Hills, AZ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/74 (2015.01); A61K 35/741 (2015.01); A61K 31/135 (2006.01); A61K 31/185 (2006.01); A61K 31/405 (2006.01); A61K 45/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/741 (2013.01); A61K 31/135 (2013.01); A61K 31/185 (2013.01); A61K 31/405 (2013.01); A61K 35/74 (2013.01); A61K 45/00 (2013.01);
Abstract

The present invention provides for microbial compositions and methods for reducing the concentration of short-chain fatty acids in the gut as a way to reduce energy uptake and manage obesity. More specifically, the invention provides for decreasing short-chain fatty acids available for absorption in the human gut, such as acetate, using one or more of: a probiotic including a homo-acetogenic, acetate oxidizing bacterium that converts acetate to H; a probiotic including an acetoclastic methanogen; a microbial electrolysis cell comprising a homo-acetogenic bacterium and/or an acetoclastic methanogen; a prebiotic that enhances the growth or function of acetate-scavenging microbiota; or a highly selective antibiotic that targets H-oxidizing methanogens.


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