The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2017
Filed:
May. 19, 2014
Applicant:
Aduro Biotech, Inc., Berkeley, CA (US);
Inventors:
Thomas W. Dubensky, Jr., Piedmont, CA (US);
David B. Kanne, Corte Madera, CA (US);
Assignee:
ADURO BIOTECH, INC., Berkeley, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); A61K 39/00 (2006.01); A61K 39/36 (2006.01); A01N 43/04 (2006.01); C07H 21/00 (2006.01); A61K 31/7084 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7084 (2013.01);
Abstract
The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING-dependent TBK1 activation and the resulting production of type I interferon.