The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2017
Filed:
Mar. 11, 2011
Kathryn Margaret Nelson, DeForest, WI (US);
Michael William Mosesson, Milwaukee, WI (US);
Anthony Pusateri, Hillsborough, NJ (US);
Erik Jordahl Forsberg, Fitchburg, WI (US);
Kathryn Margaret Nelson, DeForest, WI (US);
Michael William Mosesson, Milwaukee, WI (US);
Anthony Pusateri, Hillsborough, NJ (US);
Erik Jordahl Forsberg, Fitchburg, WI (US);
Abstract
The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called 'clots' and 'flakes' in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin.