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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9546380 B1

PDFFull Text
Date of Patent:
Jan. 17, 2017

Filed:

Jul. 28, 2015

Mgmt-based method for obtaining high yields of recombinant protein expression

Applicant:

Institut Pasteur, Paris, FR;

Inventors:

Philippe Despres, La Garenne-Colombes, FR;

Sylvie Paulous, Sarcelles, FR;

Elodie Crublet, L'Albenc, FR;

Assignee:

INSTITUT PASTEUR, Paris, FR;

Attorney:

Law Office of Salvatore Arrigo and Scott Lee, LLP

Primary Examiner:

Ganapathirama Raghu

Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 9/96 (2006.01); C12N 5/07 (2010.01); C12N 15/85 (2006.01); C12N 9/10 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); C12N 9/1007 (2013.01); C12N 9/96 (2013.01); C12N 15/625 (2013.01); C12Y 201/01063 (2013.01); C07K 2319/00 (2013.01); C07K 2319/055 (2013.01); C07K 2319/20 (2013.01); C07K 2319/21 (2013.01); C07K 2319/50 (2013.01);
Abstract

The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.

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Despres, Philippe. (2017). Mgmt-based method for obtaining high yields of recombinant protein expression (U.S. Patent No. 9546380). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9546380

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