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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9546112 B1

PDFFull Text
Date of Patent:
Jan. 17, 2017

Filed:

Mar. 22, 2011

Methods of increasing efficiency of vector penetration of target tissue

Applicants:

Thomas Voit, London, GB;

Luis Garcia, Noisy-le-Roi, FR;

Jérôme Denard, Choisy Le Roi, FR;

Fedor Svinartchouk, Villejuif, FR;

Inventors:

Thomas Voit, London, GB;

Luis Garcia, Noisy-le-Roi, FR;

Jérôme Denard, Choisy Le Roi, FR;

Fedor Svinartchouk, Villejuif, FR;

Assignees:

ASSOCIATION INSTITUT DE MYOLOGIE, , FR;

GÉNÉTHON, , FR;

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, , FR;

UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), , FR;

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, , FR;

Attorney:

Leason Ellis LLP

Primary Examiner:

Janet L Andres

Assistant Examiner:

M Franco Salvoza

Int. Cl.
CPC ...
C12N 15/00 (2006.01); A61K 35/12 (2015.01); A61N 1/30 (2006.01); C04B 35/10 (2006.01); A61K 38/17 (2006.01); A61K 38/21 (2006.01); A61K 45/06 (2006.01); C07K 16/08 (2006.01); C07K 16/18 (2006.01); C12N 15/86 (2006.01); A61K 31/522 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01); C04B 35/14 (2006.01); C04B 35/565 (2006.01); C04B 35/622 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C04B 35/10 (2013.01); A61K 31/522 (2013.01); A61K 38/00 (2013.01); A61K 38/1709 (2013.01); A61K 38/21 (2013.01); A61K 45/06 (2013.01); A61K 48/0058 (2013.01); C04B 35/14 (2013.01); C04B 35/565 (2013.01); C04B 35/622 (2013.01); C07K 14/005 (2013.01); C07K 16/081 (2013.01); C07K 16/18 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 48/0008 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14145 (2013.01); C12N 2750/14151 (2013.01); C12N 2810/6027 (2013.01);
Abstract

Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.

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