The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2017
Filed:
Feb. 17, 2015
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Antonio Jimeno, Englewood, CO (US);
Manuel Medina Hidalgo, Baltimore, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 31/7076 (2006.01); A61K 31/192 (2006.01); A61K 31/713 (2006.01); A61K 31/198 (2006.01); A61K 31/7068 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7076 (2013.01); A61K 31/192 (2013.01); A61K 31/198 (2013.01); A61K 31/7068 (2013.01); A61K 31/713 (2013.01);
Abstract
The invention includes compositions and methods of treatment of cancers susceptible to treatment with nucleotide analog chemotherapeutic agent, including cancers in which nucleotide analog resistant tumors have developed, including identifying a subject having cancer susceptible to treatment with a nucleotide analog chemotherapeutic agent and a mitotic disruptor/polo-like kinase (Plk) pathway inhibitor to a subject; and monitoring the subject for a reduction of stabilization of at least one sign or symptom of cancer.