The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2017
Filed:
Mar. 31, 2015
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Kimberly Hamad-Schifferli, Somerville, MA (US);
Salmaan H. Baxamusa, Livermore, CA (US);
Helena de Puig Guixe, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 1/30 (2006.01); A61K 9/51 (2006.01); A61K 41/00 (2006.01); A61K 47/48 (2006.01); A61K 31/713 (2006.01); A61K 31/00 (2006.01); A61N 5/06 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5115 (2013.01); A61K 31/00 (2013.01); A61K 31/713 (2013.01); A61K 41/0028 (2013.01); A61K 47/48884 (2013.01); A61N 5/062 (2013.01);
Abstract
The disclosure is directed to enabling reversible, on-demand remote control of blood clotting and clot dissolution. In one embodiment, a laser at one wavelength triggers release of a DNA thrombin inhibitor from one nanorod, which acts as an anticoagulant to stop blood clotting. Another wavelength triggers release of a specific antidote, which reverses the effect of the thrombin inhibitor, restoring blood clotting.