The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
May. 21, 2007
Applicants:
Saraswati Sukumar, Columbia, MD (US);
Liangfeng Han, Baltimore, MD (US);
Inventors:
Saraswati Sukumar, Columbia, MD (US);
Liangfeng Han, Baltimore, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C12Q 1/68 (2006.01); C07K 16/30 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C07K 16/3015 (2013.01); G01N 33/574 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01); G01N 2333/4703 (2013.01);
Abstract
The invention generally features compositions and methods that are useful for treating or diagnosing a neoplasia, in particular breast neoplasia. The invention is based in part on the observation that the basic helix loop helix transcription factor HEYL was found to be overexpressed in breast cancer cells. Accordingly, the invention provides therapeutic compositions and methods for altering the levels and expression of HEYL of the invention, thereby treating a neoplasia, as well as compositions and methods for diagnosing a neoplasia.