The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
Dec. 31, 2013
Applicant:
Novimmune S.a., Geneva, CH;
Inventors:
Greg Elson, Collonges sous Saleve, FR;
Olivier Leger, St. Sixt, FR;
Assignee:
NOVIMMUNE S.A., Geneva, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/18 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); A61K 38/177 (2013.01); A61K 38/1709 (2013.01); A61K 39/0005 (2013.01); C07K 14/47 (2013.01); C07K 14/70596 (2013.01); C07K 16/18 (2013.01); A61K 2039/505 (2013.01); A61K 2039/575 (2013.01); C07K 2317/24 (2013.01); C07K 2317/32 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01);
Abstract
This invention provides monoclonal antibodies that recognize the Toll-like Receptor 4/MD-2 receptor complex, and monoclonal antibodies that recognize the TLR4/MD2 complex as well as TLR4 when not complexed with MD-2. The invention further provides methods of using the monoclonal antibodies as therapeutics. This invention also provides soluble chimeric proteins, methods of expressing and purifying soluble chimeric proteins, and methods of using soluble chimeric proteins as therapeutics, in screening assays and in the production of antibodies.