The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
Jan. 25, 2012
Yaron Hadari, Harrison, NY (US);
Susanne Radke, Hamden, CT (US);
Joseph Schlessinger, Woodbridge, CT (US);
Yoshihisa Suzuki, Hamden, CT (US);
Yaron Hadari, Harrison, NY (US);
Susanne Radke, Hamden, CT (US);
Joseph Schlessinger, Woodbridge, CT (US);
Yoshihisa Suzuki, Hamden, CT (US);
KOLLTAN PHARMACEUTICALS, INC., New Haven, CT (US);
Abstract
Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.