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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9540396 B1

PDFFull Text
Date of Patent:
Jan. 10, 2017

Filed:

Nov. 01, 2011

6-arylamino pyridone carboxamide as mek inhibitors

Applicants:

Dengming Xiao, Beijing, CN;

LI Zhu, Beijing, CN;

Yuandong HU, Beijing, CN;

Shixin Wang, Beijing, CN;

Rong Yu, Beijing, CN;

Wei HU, Beijing, CN;

Zhi Liang, Beijing, CN;

Xijie Liu, Beijing, CN;

Quan HU, Beijing, CN;

Inventors:

Dengming Xiao, Beijing, CN;

Li Zhu, Beijing, CN;

Yuandong Hu, Beijing, CN;

Shixin Wang, Beijing, CN;

Rong Yu, Beijing, CN;

Wei Hu, Beijing, CN;

Zhi Liang, Beijing, CN;

Xijie Liu, Beijing, CN;

Quan Hu, Beijing, CN;

Assignees:

Centaurus Biopharma Co., Ltd., Beijing, CN;

Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Jiangsu, CN;

Attorney:

Kilpatrick Townsend & Stockton LLP

Primary Examiner:

Rita Desai

Assistant Examiner:

Ben S Michelson

Int. Cl.
CPC ...
C07D 471/02 (2006.01); C07D 491/02 (2006.01); C07D 498/02 (2006.01); C07D 513/02 (2006.01); C07D 515/02 (2006.01); A61K 31/44 (2006.01); C07D 513/04 (2006.01); A61K 31/4355 (2006.01); A61K 31/4365 (2006.01); A61K 31/437 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/437 (2013.01); A61K 31/4355 (2013.01); A61K 31/4365 (2013.01); A61K 31/4545 (2013.01); A61K 31/5377 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01);
Abstract

The invention provides novel substituted 6-arylamino pyridone carboxamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, poly-morph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.

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