The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
May. 03, 2014
Applicant:
Microbiotix, Inc., Worcester, MA (US);
Inventors:
Timothy J. Opperman, Arlington, MA (US);
Son T. Nguyen, West Boylston, MA (US);
Steven M. Kwasny, Blackstone, MA (US);
Xiaoyuan Ding, North Providence, RI (US);
Assignee:
Microbiotix, Inc., Worcester, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); C07D 491/052 (2006.01); A61K 31/551 (2006.01); C07D 493/04 (2006.01); C07D 513/04 (2006.01); A61K 45/06 (2006.01); A61K 31/436 (2006.01); A61K 31/496 (2006.01); A61K 31/541 (2006.01); A01N 43/90 (2006.01); A01N 47/44 (2006.01); A61K 31/5383 (2006.01); A61K 31/553 (2006.01);
U.S. Cl.
CPC ...
C07D 491/052 (2013.01); A01N 43/90 (2013.01); A01N 47/44 (2013.01); A61K 31/436 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01); A61K 31/541 (2013.01); A61K 31/551 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 493/04 (2013.01); C07D 513/04 (2013.01);
Abstract
Novel compounds are disclosed having the structure of Formula I: wherein, The compounds are potent bacterial efflux pump inhibitors (EPIs). Such compounds are useful to potentiate the antimicrobial activity of antimicrobial compounds such as beta-lactam antibiotics and quinolone antibiotics against Gram-negative bacteria.