The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
Aug. 16, 2012
Applicants:
Michael Ohlmeyer, Plainsboro, NJ (US);
Goutham Narla, Beachwood, OH (US);
Neil Dhawan, New York, NY (US);
David Kastrinsky, Fair Lawn, NJ (US);
Inventors:
Michael Ohlmeyer, Plainsboro, NJ (US);
Goutham Narla, Beachwood, OH (US);
Neil Dhawan, New York, NY (US);
David Kastrinsky, Fair Lawn, NJ (US);
Assignee:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/55 (2006.01); C07D 223/26 (2006.01); C07D 223/28 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); C07D 417/06 (2006.01); C07D 279/28 (2006.01); C07C 311/20 (2006.01); C07D 207/26 (2006.01); C07D 211/76 (2006.01); C07D 307/94 (2006.01); C07D 311/96 (2006.01); C09B 21/00 (2006.01);
U.S. Cl.
CPC ...
C07D 409/12 (2013.01); C07C 311/20 (2013.01); C07D 207/26 (2013.01); C07D 211/76 (2013.01); C07D 223/28 (2013.01); C07D 279/28 (2013.01); C07D 307/94 (2013.01); C07D 311/96 (2013.01); C07D 401/12 (2013.01); C07D 417/06 (2013.01); C09B 21/00 (2013.01);
Abstract
Tricyclic chemical modulators of FOXO transcription factor proteins are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced depression, inflammation, and acne. The compounds are of the following phenothiazine, dibenzoazepine and annulene and similar genera: