The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 10, 2017

Filed:

Jun. 07, 2012
Applicants:

Scott L. Childs, Atlanta, GA (US);

Shreenivas R. Lingireddy, Atlanta, GA (US);

Nathan Barishansky, Teaneck, NJ (US);

Inventors:

Scott L. Childs, Atlanta, GA (US);

Shreenivas R. Lingireddy, Atlanta, GA (US);

Nathan Barishansky, Teaneck, NJ (US);

Assignee:

AMPLIO PHARMA, LLC, Leonia, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/00 (2006.01); A61K 31/445 (2006.01); C07D 401/04 (2006.01); A61K 31/4035 (2006.01); C07C 55/07 (2006.01); C07C 55/08 (2006.01); C07C 59/255 (2006.01); C07C 65/03 (2006.01); C07C 275/02 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/4035 (2013.01); C07C 55/07 (2013.01); C07C 55/08 (2013.01); C07C 59/255 (2013.01); C07C 65/03 (2013.01); C07C 275/02 (2013.01);
Abstract

The invention relates to novel crystalline forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione, including a novel urea cocrystal of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione; a novel gallic acid cocrystal of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione; a novel propyl gallate cocrystal of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione; and a novel L-tartaric acid cocrystal of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione. The preparation and characterization of the novel crystalline forms according to various embodiments of the invention are described. The invention also relates to pharmaceutical compositions containing the novel crystalline forms, and the therapeutic use of the novel crystalline forms.


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