The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
Jul. 02, 2010
Applicants:
Paul A. Marks, Washington, CT (US);
Weisheng Xu, Forest Hills, NY (US);
Mandana Namdar, London, GB;
Inventors:
Assignee:
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A01N 37/28 (2006.01); A61K 31/19 (2006.01); A01N 43/76 (2006.01); A61K 31/42 (2006.01); C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61K 31/704 (2006.01); A61K 31/167 (2006.01); A61K 31/422 (2006.01); A61K 31/7048 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/704 (2013.01); A61K 31/167 (2013.01); A61K 31/19 (2013.01); A61K 31/422 (2013.01); A61K 31/7048 (2013.01); A61K 45/06 (2013.01);
Abstract
This invention provides methods for treating a subject afflicted with cancer, comprising concurrently administering (i) an HDAC 6-selective inhibitor and (ii) a suitable cytotoxic agent such as SAHA, doxorubicin or etoposide. This invention also provides methods for inducing the death of a transformed cell such as a cancer cell, comprising concurrently contacting the cell with (i) an HDAC 6-selective inhibitor and (ii) a suitable cytotoxic agent such as SAHA, doxorubicin or etoposide.