The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
Dec. 06, 2012
Friesland Brands B.v., Amersfoort, NL;
Rijksuniversiteit Groningen, Groningen, NL;
Darling Ingredients Nederland B.v., Son, NL;
Erik Sallomons, Westerbork, NL;
Maarten Hotse Wilbrink, Groningen, NL;
Peter Sanders, Groningen, NL;
Johannis Paulus Kamerling, Groningen, NL;
Catherina Anna van Vuure, Helmond, NL;
Johannes Adrianus Hage, Arkel, NL;
RIJKSUNIVERSITEIT GRONINGEN, Groningen, NL;
Abstract
The invention relates to a method for providing analogs of human milk oligosaccharides (HMO), in particular oligosaccharides containing terminal sialic acid. The method comprises the steps of: a) providing a source of non-digestible galactooligosaccharides (GOS) containing at least two terminally bonded β-linked galactose residues; b) providing a sialic acid donor having (α2-3)-sialylated O-glycans; c) contacting said GOS with said sialic acid donor in the presence of an enzyme having trans-sialidase activity in an enzyme reaction mixture; and d) isolating from said enzyme reaction mixture a fraction comprising at least 20 percent by weight of disialylated galactooligosaccharides (di-Sia-GOS) based on the dry matter.