The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
Aug. 06, 2015
Applicant:
Aerpio Therapeutics, Inc., Cincinnati, OH (US);
Inventor:
Kevin Peters, Cincinnati, OH (US);
Assignee:
AERPIO THERAPEUTICS, INC., Cincinnati, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07D 277/30 (2006.01); A61K 31/427 (2006.01); A61K 38/45 (2006.01); A61K 39/395 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/427 (2013.01); A61K 31/00 (2013.01); A61K 38/45 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); A61K 2039/505 (2013.01); C07K 2319/55 (2013.01);
Abstract
The present invention relates to combination therapies comprising at least one activator of Tie-2 and immunotherapies that target immune checkpoints. Combination therapies of the disclosure can provide therapeutic effects not obtained with singly-administered immunotherapies. Combination therapies can be used to increase the therapeutic efficacy of an immunotherapy, to provide lower dosages of an immunotherapy being administered, to lower a toxicity of an immunotherapy, or to manage a side effect of an immunotherapy.