The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2017
Filed:
Apr. 25, 2014
Korea Ocean Research and Development Institute, Incheon, KR;
Joung Han Yim, Gyeonggi-do, KR;
Il Chan Kim, Gyeonggi-do, KR;
Sung Gu Lee, Incheon, KR;
Doc Kyu Kim, Incheon, KR;
Se Jong Han, Gyunggi-do, KR;
Hyoung Seok Lee, Seoul, KR;
Sung Jin Kim, Incheon, KR;
Tai Kyoung Kim, Incheon, KR;
Pil-Sung Kang, Incheon, KR;
Heeyong Park, Gyeonggi-do, KR;
Ha Ju Park, Gyeonggi-do, KR;
Suhkneung Pyo, Seoul, KR;
Babita Paudel-Bhattarai, Goettingen, DE;
KOREA OCEAN RESEARCH AND DEVELOPMENT INSTITUTE, Incheon, KR;
Abstract
The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.