The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2017
Filed:
May. 09, 2012
Applicants:
Ann Brigé, Ertvelde, BE;
Peter Schotte, De Pinte, BE;
Bart Walcarius, Gentbrugge, BE;
Inventors:
Assignee:
Ablynx N.V., Zwijinaarde, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C07K 16/00 (2006.01); C12N 15/81 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C12N 15/815 (2013.01); C07K 2317/14 (2013.01); C07K 2317/22 (2013.01); C07K 2317/569 (2013.01); C12P 21/02 (2013.01);
Abstract
Methods are provided for the expression of immunoglobulin variable domains that are secreted into the culture medium. The methods provide for the production of homogeneous immunoglobulin variable domains in which the proportion of product-related variants that comprise, at the N-terminus, at least one redundant amino acid residue derived from the secretion signal is strongly reduced or absent.