The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2017
Filed:
Sep. 28, 2011
Timothy Cardozo, New York, NY (US);
Xiang-peng Kong, New York, NY (US);
Susan Zolla-pazner, New York, NY (US);
Shan LU, Franklin, MA (US);
Shixia Wang, Northborough, MA (US);
Maxim Totrov, San Diego, CA (US);
Timothy Cardozo, New York, NY (US);
Xiang-peng Kong, New York, NY (US);
Susan Zolla-Pazner, New York, NY (US);
Shan Lu, Franklin, MA (US);
Shixia Wang, Northborough, MA (US);
Maxim Totrov, San Diego, CA (US);
New York University, New York, NY (US);
University of Massachusetts, Boston, MA (US);
Molsoft LLC, San Diego, CA (US);
Abstract
The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gp120 protein and not other known epitopes of the HIV gp120 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.