The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2017
Filed:
Jul. 30, 2015
Applicant:
Brock University, St. Catharines, Ontario, CA;
Inventors:
Tomas Hudlicky, St. Catharines, CA;
Ales Machara, Brevnov, CZ;
Assignee:
Brock University, St. Catherines, Ontario, CA;
Primary Examiner:
Int. Cl.
CPC ...
C07D 489/08 (2006.01); C07D 489/02 (2006.01);
U.S. Cl.
CPC ...
C07D 489/02 (2013.01); C07D 489/08 (2013.01);
Abstract
The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone and nalbuphone. One feature of this process is an intramolecular functional group transfer from the C-14 hydroxyl to the N-17 nitrogen atom following a palladium-catalyzed N-demethylation.