The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2017
Filed:
Jun. 21, 2013
Applicant:
Institute for Cancer Research, Philadelphia, PA (US);
Inventors:
Anna Marie Skalka, Princeton, NJ (US);
Mark Andrake, Huntingdon Valley, PA (US);
Ravi Shankar Bojja, Philadelphia, PA (US);
Assignee:
Institute for Cancer Research, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/34 (2006.01); C07K 16/10 (2006.01); A61K 39/395 (2006.01); C12Q 1/18 (2006.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); C12N 9/22 (2013.01); C12Q 1/18 (2013.01); C12Q 1/34 (2013.01); C07K 16/1054 (2013.01); C12N 2740/11022 (2013.01); C12N 2740/16211 (2013.01); C12N 2740/16222 (2013.01); G01N 2333/161 (2013.01); G01N 2333/922 (2013.01);
Abstract
Methods to inhibit the formation of retrovirus integrase reaching dimers, to dissociate retrovirus integrase reaching dimers, and to stabilize retrovirus integrase reaching dimers in a conformation in which retrovirus DNA-to host cell DNA integration activity of the integrase is inhibited are provided. Methods for treating a retrovirus infection, which target retrovirus integrase reaching dimer formation and/or stability are also provided.