The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 03, 2017

Filed:

Apr. 20, 2015
Applicant:

Cerion, Llc, Rochester, NY (US);

Inventors:

Kenneth Joseph Reed, Brighton, NY (US);

Wendi Ann Costanzo, Webster, NY (US);

Joseph Samuel Erlichman, Canton, NY (US);

Eric Leslie Bell, Webster, NY (US);

Assignee:

CERION, LLC, Rochester, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/16 (2006.01); A61K 33/24 (2006.01); A61K 9/10 (2006.01); B82Y 5/00 (2011.01); B01J 13/02 (2006.01);
U.S. Cl.
CPC ...
A61K 33/24 (2013.01); A61K 9/10 (2013.01); A61K 9/16 (2013.01); A61K 9/1694 (2013.01); B01J 13/02 (2013.01); B82Y 5/00 (2013.01); C01P 2004/64 (2013.01);
Abstract

A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, citric acid and ethylenediaminetetraacetic acid in a predetermined ratio, an oxidant, and water is provided along with temperature conditions to directly form, without isolation, a stable dispersion of cerium oxide nanoparticles. These biocompatible cerium oxide nanoparticles may be used to prevent and/or treat oxidative stress related diseases, such as stroke, relapse/remitting multiple sclerosis, chronic-progressive multiple sclerosis, amyotrophic lateral sclerosis, and ischemic reperfusion injury.


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