The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2017
Filed:
Apr. 18, 2010
Aleksandar Filip Radovic-moreno, State College, PA (US);
Weiwei Gao, Cambridge, MA (US);
Archana Swami, Everett, MA (US);
Gershon Golomb, Efrat, IL;
Robert S. Langer, Newton, MA (US);
Omid C. Farokhzad, Chestnut Hill, MA (US);
Aleksandar Filip Radovic-Moreno, State College, PA (US);
Weiwei Gao, Cambridge, MA (US);
Archana Swami, Everett, MA (US);
Gershon Golomb, Efrat, IL;
Robert S. Langer, Newton, MA (US);
Omid C. Farokhzad, Chestnut Hill, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The Brigham and Women's Hospital Inc., Boston, MA (US);
Abstract
The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like. The present invention also relates to particles containing a cleavable bond component and one or more fluorescence resonance energy transfer (FRET) pairs as well as methods of detecting the cleavage of the cleavable bond component of such particles.