The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Oct. 27, 2010
Applicants:
Stephen R. Hamilton, Enfield, NH (US);
Terrance A. Stadheim, Lyme, NH (US);
Inventors:
Stephen R. Hamilton, Enfield, NH (US);
Terrance A. Stadheim, Lyme, NH (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12N 15/81 (2006.01); C12N 9/48 (2006.01); C12P 21/00 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/81 (2013.01); C12N 9/48 (2013.01); C12P 21/005 (2013.01); C12P 21/02 (2013.01); Y02P 20/52 (2015.11);
Abstract
The present invention related to methods and compositions for producing therapeutic proteins in yeast cell lines, and in particular, lacking dipeptidyl aminopeptidase (DAP) activity. DAP activity has been eliminated by genetically modifying acell line such that STE13 and DAP2 have been deleted.