The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Jan. 03, 2013
Applicant:
Medical Research Council, London, GB;
Inventors:
Andrew Griffiths, Cambridge, GB;
Dan Tawfik, Cambridge, GB;
Assignee:
Medical Research Council, London, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C12Q 1/00 (2006.01); C12Q 1/70 (2006.01); C12P 21/06 (2006.01); C40B 10/00 (2006.01); C40B 30/08 (2006.01); C40B 30/10 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1058 (2013.01); C12N 15/1062 (2013.01); C12N 15/1075 (2013.01); C12Q 1/6811 (2013.01);
Abstract
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalizing genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.