The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 2016

Filed:

Aug. 04, 2015
Applicants:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Eastern Michigan University, Ypsilanti, MI (US);

Inventors:

Daniel A. Lawrence, Ann Arbor, MI (US);

Cory Emal, Ann Arbor, MI (US);

Jacqueline Cale, Minneapolis, MN (US);

Enming Joe Su, Ann Arbor, MI (US);

Mark Warnock, Brighton, MI (US);

Shih-Hon Li, Ypsilanti, MI (US);

Jeanne Ann Cupp, Fenton, MI (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 15/203 (2006.01); A61K 31/7034 (2006.01); A61K 38/17 (2006.01); C07C 69/94 (2006.01); A61K 31/235 (2006.01); C07C 271/22 (2006.01); A61K 31/27 (2006.01); C07C 311/29 (2006.01); A61K 31/18 (2006.01); C07C 235/68 (2006.01); A61K 31/166 (2006.01); C07D 213/82 (2006.01); A61K 31/444 (2006.01); C07D 295/192 (2006.01); A61K 31/495 (2006.01); C07C 311/49 (2006.01); C07D 295/26 (2006.01); A61K 31/50 (2006.01); A61K 31/5375 (2006.01); C07C 69/88 (2006.01); C07C 69/90 (2006.01); C07C 229/12 (2006.01); C07C 229/34 (2006.01); C07C 271/54 (2006.01); C07H 13/08 (2006.01); A61K 38/48 (2006.01); C07D 295/195 (2006.01);
U.S. Cl.
CPC ...
C07H 15/203 (2013.01); A61K 31/166 (2013.01); A61K 31/18 (2013.01); A61K 31/235 (2013.01); A61K 31/27 (2013.01); A61K 31/444 (2013.01); A61K 31/495 (2013.01); A61K 31/50 (2013.01); A61K 31/5375 (2013.01); A61K 31/7034 (2013.01); A61K 38/1741 (2013.01); A61K 38/482 (2013.01); C07C 69/88 (2013.01); C07C 69/90 (2013.01); C07C 69/94 (2013.01); C07C 229/12 (2013.01); C07C 229/34 (2013.01); C07C 235/68 (2013.01); C07C 271/22 (2013.01); C07C 271/54 (2013.01); C07C 311/29 (2013.01); C07C 311/49 (2013.01); C07D 213/82 (2013.01); C07D 295/195 (2013.01); C07D 295/26 (2013.01); C07H 13/08 (2013.01); C07C 2101/14 (2013.01); C12Y 304/21073 (2013.01);
Abstract

The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.


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