The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Jan. 13, 2016
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Yong Zhang, West Windsor, NJ (US);
Ivar M. McDonald, East Haddam, CT (US);
Naidu S. Chowdari, Sunnyvale, CA (US);
Tram N. Huynh, Pennington, NJ (US);
Robert M. Borzilleri, Carversville, PA (US);
Sanjeev Gangwar, Foster City, CA (US);
Assignee:
BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 519/00 (2006.01); A61K 47/48 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07D 519/00 (2013.01); A61K 47/48538 (2013.01); A61K 47/48561 (2013.01); C07D 487/04 (2013.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); C07K 16/30 (2013.01); C07K 2317/76 (2013.01);
Abstract
Benzodiazepine dimers having a structure represented by wherein Ris wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).