The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Mar. 28, 2013
Nerviano Medical Sciences S.r.l., Nerviano, IT;
Italo Beria, Nerviano, IT;
Michele Caruso, Milan, IT;
Vittoria Lupi, Milan, IT;
Paolo Orsini, Legnano, IT;
Matteo Salsa, Bellinzago Novarese, IT;
Achille Panzeri, Merate, IT;
NERVIANO MEDICAL SCIENCES S.R.L., Nerviano (MI), IT;
Abstract
The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a DNA-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them. The invention also relates to the use of this novel class of alkylating agents in the preparation of conjugates.