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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9527855 B1

PDFFull Text
Date of Patent:
Dec. 27, 2016

Filed:

Oct. 02, 2015

Process for preparing chiral dipeptidyl peptidase-iv inhibitors

Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Merck Sharp & Dohme Ltd., Hoddesdon, GB;

Inventors:

Michael J. Zacuto, Jersey City, NJ (US);

Robert F. Dunn, Towaco, NJ (US);

Aaron J. Moment, Scotch Plains, NJ (US);

Jacob M. Janey, New York, NY (US);

David Lieberman, London, GB;

Faye Sheen, Hoddesdon, GB;

Nadine Bremeyer, Hoddesdon, GB;

Jeremy Scott, Hoddesdon, GB;

Jeffrey T. Kuethe, Somerset, NJ (US);

Lushi Tan, Edison, NJ (US);

Qinghao Chen, Edison, NJ (US);

Assignees:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Merck Sharp & Dohme Ltd., Hoddesdon, GB;

Attorneys:

Janet E. Fair

Anna L. Cocuzzo

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/4439 (2006.01); A61K 31/4985 (2006.01); A61K 31/513 (2006.01); A61K 31/4162 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4439 (2013.01); A61K 31/4985 (2013.01); A61K 31/513 (2013.01); A61K 31/4162 (2013.01); C07B 2200/13 (2013.01); Y02P 20/55 (2015.11);
Abstract

A process for the preparation of pyrazolopyrolidines of structural formula I: and W is or P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.

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Zacuto, Michael. (2016). Process for preparing chiral dipeptidyl peptidase-iv inhibitors (U.S. Patent No. 9527855). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9527855

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