The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 2016

Filed:

Aug. 06, 2015
Applicant:

Pfizer Inc., New York, NY (US);

Inventors:

Jennifer Elizabeth Davoren, Cambridge, MA (US);

Amy Beth Dounay, Colorado Springs, CO (US);

Ivan Viktorovich Efremov, Chesnut Hill, MA (US);

David Lawrence Firman Gray, Groton, MA (US);

Scot Richard Mente, Arlington, MA (US);

Steven Victor O'Neil, East Lyme, CT (US);

Bruce Nelsen Rogers, Belmont, MA (US);

Chakrapani Subramanyam, South Glastonbury, CT (US);

Lei Zhang, Auburndale, MA (US);

Assignee:

PFIZER INC., New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 401/04 (2006.01); A61K 31/437 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/437 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides of the foregoing; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, salts or N-oxides, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), ADHD, impulsivity, compulsive gambling, overeating, autism spectrum disorder, MCI, age-related cognitive decline, dementia, RLS, Parkinson's disease, Huntington's chorea, anxiety, depression, MDD, TRD, and bipolar disorder.


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